In 2011, Ekta Kapoor had infamously quipped, "Who is Radhika Apte?" on a celebrity chat show. Her actor-brother, Tusshar Kapoor, who also featured in that episode alongside her, was asked to name the sexiest actresses and he said: 'Kareena Kapoor, Priyanka Chopra, Katrina Kaif...' and then paused to think. Ekta quipped, "Radhika Apte?" At that point, show host and filmmaker Karan Johar asked, 'Who is this Radhika?' and Ekta added, 'Exactly! Who is Radhika Apte?'

While starting out in filmdom, Radhika Apte did a bit role in Mahesh Manjrekar’s 2005 film 'Vaah! Life Ho Toh Aisi!' starring Sanjay Dutt, Shahid Kapoor and Amrita Rao