They're quitting!

Both Katherine Heiglu00a0and BFF T R Knight are reportedly leaving the series that made them household names.

Grey's Anatomy won'tu00a0 seem the same without the duo that was responsible for many heart-warming angles on the show.

"Yes, she is [leaving]," co-star James Pickens Jr (Dr Richard Webber) tells Us Weekly. "Wherever Katherine goes, I wish her nothing but the best.

[TR Knight's] going too. He just wanted to pursue other career paths."

"Right now, the whole thing is in the hands of their agents and ABC's lawyers," an insider tells EW.

"Something will probably be worked out soon, but it's a safe bet that Katherine and T R won't be returning as series regulars next season."